NEUROSURGERY Report

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Posts Tagged ‘Brain tissue oxygen tension

Free CME Article: Initial Clinical Scales After Severe TBI

Background: Prediction of clinical course and outcome after severe traumatic brain injury (TBI) is important.

Objective: To examine whether clinical scales (Glasgow Coma Scale [GCS], Injury Severity Score [ISS], and Acute Physiology and Chronic Health Evaluation II [APACHE II]) or radiographic scales based on admission computed tomography (Marshall and Rotterdam) were associated with intensive care unit (ICU) physiology (intracranial pressure [ICP], brain tissue oxygen tension [PbtO2]), and clinical outcome after severe TBI.

Methods: One hundred one patients (median age, 41.0 years; interquartile range [26-55]) with severe TBI who had ICP and PbtO2 monitoring were identified. The relationship between admission GCS, ISS, APACHE II, Marshall and Rotterdam scores and ICP, PbtO2, and outcome was examined by using mixed-effects models and logistic regression.

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Free Article: Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury

Free full text access.

Oddo, Mauro MD; Nduom, Edjah MD; Frangos, Suzanne RN; MacKenzie, Larami MD; Chen, Isaac MD; Maloney-Wilensky, Eileen MSN; Kofke, W. Andrew MD; Levine, Joshua M. MD; LeRoux, Peter D. MD

BACKGROUND: Pulmonary complications are frequently observed after severe traumatic brain injury (TBI), but little is known about the consequences of lung injury on brain tissue oxygenation and metabolism.

OBJECTIVE: We examined the association between lung function and brain tissue oxygen tension (PbtO2) in patients with severe TBI.

METHODS: We analyzed data from 78 patients with severe, nonpenetrating TBI who underwent continuous PbtO2 and intracranial pressure monitoring. Acute lung injury was defined by the presence of pulmonary infiltrates with a PaO2/FiO2 (PF) ratio less than 300 and the absence of left ventricular failure. A total of 587 simultaneous measurements of PbtO2 and PF ratio were examined using longitudinal data analysis.

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Written by NEUROSURGERY® Editorial Office

August 17, 2010 at 9:08 AM

Free Article: Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury

Free full text access.

Oddo, Mauro MD; Nduom, Edjah MD; Frangos, Suzanne RN; MacKenzie, Larami MD; Chen, Isaac MD; Maloney-Wilensky, Eileen MSN; Kofke, W. Andrew MD; Levine, Joshua M. MD; LeRoux, Peter D. MD

BACKGROUND: Pulmonary complications are frequently observed after severe traumatic brain injury (TBI), but little is known about the consequences of lung injury on brain tissue oxygenation and metabolism.

OBJECTIVE: We examined the association between lung function and brain tissue oxygen tension (PbtO2) in patients with severe TBI.

METHODS: We analyzed data from 78 patients with severe, nonpenetrating TBI who underwent continuous PbtO2 and intracranial pressure monitoring. Acute lung injury was defined by the presence of pulmonary infiltrates with a PaO2/FiO2 (PF) ratio less than 300 and the absence of left ventricular failure. A total of 587 simultaneous measurements of PbtO2 and PF ratio were examined using longitudinal data analysis. Read the rest of this entry »

Written by NEUROSURGERY® Editorial Office

July 23, 2010 at 8:44 AM

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