Ahead of Print: High-Definition Fiber Tractography of the Human Brain

Background: High Definition Fiber Tracking (HDFT) is a novel combination of processing, reconstruction, and tractography methods that can track white matter fibers from cortex, through complex fiber crossings, to cortical and subcortical targets with sub-voxel resolution.

Objective: To perform neuroanatomical validation of HDFT and investigate its neurosurgical applications.

Methods: Six neurologically healthy adults and 36 patients with brain lesions were studied. Diffusion Spectrum Imaging (DSI) data were reconstructed using a Generalized Q-Ball Imaging (GQI) approach. Fiber dissection studies were performed in 20 human brains and selected dissection results were compared with tractography.