NEUROSURGERY Report

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Posts Tagged ‘Lung function

Ahead of Print: DBS Modulates Airways Resistance

Background: Deep brain stimulation (DBS) of subcortical brain areas such as the periaqueductal grey (PAG) and subthalamic nucleus (STN) has been shown to alter cardiovascular autonomic performance. The supramedullary circuitry controlling respiratory airways is not well defined and has not been tested in humans.

Objective: Direct electrical stimulation via DBS macroelectrodes was used to test whether airway resistance could be manipulated by these areas in awake humans.

Methods: Thirty-seven patients with in-dwelling deep brain electrodes for movement disorders or chronic pain underwent spirometry as per the European Respiratory Society guidelines. Testing was performed three times On and three times Off stimulation, randomly, in which patients were blinded. Thoracic diameter changes were measured by a circumferential pressure-sensitive thoracic band. Ten PAG and ten STN patients were tested. To control for confounding pain and movement disorder relief, the sensory thalamus in seven patients and globus pallidus interna in ten patients, respectively, were also tested.

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Written by NEUROSURGERY® Editorial Office

January 2, 2012 at 8:00 AM

Free Article: Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury

Free full text access.

Oddo, Mauro MD; Nduom, Edjah MD; Frangos, Suzanne RN; MacKenzie, Larami MD; Chen, Isaac MD; Maloney-Wilensky, Eileen MSN; Kofke, W. Andrew MD; Levine, Joshua M. MD; LeRoux, Peter D. MD

BACKGROUND: Pulmonary complications are frequently observed after severe traumatic brain injury (TBI), but little is known about the consequences of lung injury on brain tissue oxygenation and metabolism.

OBJECTIVE: We examined the association between lung function and brain tissue oxygen tension (PbtO2) in patients with severe TBI.

METHODS: We analyzed data from 78 patients with severe, nonpenetrating TBI who underwent continuous PbtO2 and intracranial pressure monitoring. Acute lung injury was defined by the presence of pulmonary infiltrates with a PaO2/FiO2 (PF) ratio less than 300 and the absence of left ventricular failure. A total of 587 simultaneous measurements of PbtO2 and PF ratio were examined using longitudinal data analysis.

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Written by NEUROSURGERY® Editorial Office

August 17, 2010 at 9:08 AM

Free Article: Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury

Free full text access.

Oddo, Mauro MD; Nduom, Edjah MD; Frangos, Suzanne RN; MacKenzie, Larami MD; Chen, Isaac MD; Maloney-Wilensky, Eileen MSN; Kofke, W. Andrew MD; Levine, Joshua M. MD; LeRoux, Peter D. MD

BACKGROUND: Pulmonary complications are frequently observed after severe traumatic brain injury (TBI), but little is known about the consequences of lung injury on brain tissue oxygenation and metabolism.

OBJECTIVE: We examined the association between lung function and brain tissue oxygen tension (PbtO2) in patients with severe TBI.

METHODS: We analyzed data from 78 patients with severe, nonpenetrating TBI who underwent continuous PbtO2 and intracranial pressure monitoring. Acute lung injury was defined by the presence of pulmonary infiltrates with a PaO2/FiO2 (PF) ratio less than 300 and the absence of left ventricular failure. A total of 587 simultaneous measurements of PbtO2 and PF ratio were examined using longitudinal data analysis. Read the rest of this entry »

Written by NEUROSURGERY® Editorial Office

July 23, 2010 at 8:44 AM

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