NEUROSURGERY Report

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Posts Tagged ‘Recurrence

Free Editor Choice with CME: Solitaire AB Stent-Assisted Coiling of Wide-Necked Intracranial Aneurysms

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Screen Shot 2014-08-25 at 7.50.31 AMBackground: Endovascular treatment of intracranial aneurysms can be technically difficult when the neck is wide. The Solitaire AB stent (Covidien, Irvine, California), the only fully retrieved stent, assists in the coiling of wide-neck intracranial aneurysms.

Objective: To evaluate the mid-term angiographic follow-up of wide-necked aneurysms treated with the Solitaire AB stent.

Methods: SOLARE (SOLitaire Aneurysm Remodeling) is a consecutive, prospective study conducted in 7 European centers. A core laboratory evaluated the postoperative and mid-term (6 month ± 15 days) angiographic results by using the Raymond classification Scale. Recanalization was defined as worsening, and progressive thrombosis was defined as improvement in the Raymond scale score.

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Written by NEUROSURGERY® Editorial Office

August 25, 2014 at 8:00 AM

Ahead of Print: Operative Management of Dedifferentiated Sacral Chordomas

Background: Dedifferentiated chordomas are rare high-grade malignant spinal tumors for which there is minimal information to help guide treatment.

Objective: To identify prognostic factors associated with increased risk of local recurrence, metastases and reduced survival in a cohort of patients undergoing sacrectomy for ‘de novo’ dedifferentiated sacral chordoma.

Methods: Review of ten patients undergoing sacrectomy for histologically-confirmed dedifferentiated chordoma at a specialist center. There were six males and four females with a mean age 66.7 years (57-80) and mean follow-up 36.7 months (3-98). Data on prognostic factors were collected.

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Written by NEUROSURGERY® Editorial Office

August 13, 2014 at 8:00 AM

Free Article: Greater Extent of Resection Improves Ganglioglioma Recurrence-Free Survival in Children

Background: Gangliogliomas are rare, low-grade, glial-neural tumors that are most often found in children. They can recur with varying frequency; yet few data are available that adequately predict such events.

Objective: To review our institution’s large series of gangliogliomas in children and identify clinical features that predict recurrence-free survival.

Methods: Clinical records were retrospectively reviewed from 1990 to 2011. Fifty-three children were identified, and pertinent clinical features were analyzed against survival data to categorize lesions at high risk of recurrence.

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Written by NEUROSURGERY® Editorial Office

July 1, 2014 at 8:00 AM

Ahead of Print: Resection Improves Pediatric Ganglioglioma Outcome

Background: Gangliogliomas are rare, low-grade, glial-neural tumors most often found in children. They can recur with varying frequency; yet, little data are available that adequately predict such events.

Objective: To review our institution’s large series of gangliogliomas in children and identify clinical features that predict recurrence-free survival.

Methods: Clinical records were retrospectively reviewed from 1990 through 2011. Fifty-three children were identified, and pertinent clinical features were analyzed against survival data to categorize lesions at high risk for recurrence.

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Written by NEUROSURGERY® Editorial Office

May 21, 2014 at 8:00 AM

Ahead of Print: Laser Ablation for Recurrent Metastasis

Screen Shot 2014-04-08 at 1.52.58 PMBackground: Enhancing lesions that progress after stereotactic radiosurgery (SRS) are often tumor recurrence or radiation necrosis. Magnetic resonance-guided laser induced thermal therapy (LITT) is currently being explored for minimally invasive treatment of intracranial neoplasms.

Objective: To report the largest series to date of local control with LITT for the treatment of recurrent enhancing lesions after SRS for brain metastases.

Methods: Patients with recurrent metastatic intracranial tumors or radiation necrosis who had previously undergone radiosurgery and KPS>70 were eligible for LITT. Sixteen patients underwent a total of 17 procedures. The primary endpoint was local control using MRI scans at intervals of >4 weeks. Radiographic outcomes were followed prospectively until death or local recurrence (defined as >25% increase in volume when compared with the 24-hour post-procedure scan).

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Written by NEUROSURGERY® Editorial Office

May 8, 2014 at 8:00 AM

Ahead of Print: Colloid Cyst Remnants

The_Significance_of_Cyst_Remnants_FollowingBackground: Controversy surrounds the fate of cyst remnants following endoscopic colloid cyst resection.

Objective: Our study evaluated recurrence rates in patients with total endoscopic resection of colloid cysts versus those with coagulated cyst remnants.

Methods: Sixty-five consecutive patients and 67 procedures for endoscopic resection of colloid cysts from 1995 to 2011 were reviewed. Degree of resection was based upon intra-operative assessment and post-operative MRI. Recurrence rates were compared between patients with complete resection versus coagulated cyst remnants.

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Written by NEUROSURGERY® Editorial Office

May 17, 2013 at 8:00 AM

Ahead of Print: Comparison of Silent Corticotrophic Adenomas to Hormone-Negative Adenomas

Screen Shot 2013-04-08 at 7.26.21 AMBackground: Silent corticotrophic adenomas (SCAs) stain adrenocorticotropic hormone (ACTH)+ without causing Cushing’s disease. SCAs are reportedly more aggressive, but information comes from small series.

Objective: To determine whether SCAs behave more aggressively than Hormone-Negative Adenomas (HNAs), and characterize SCA ACTH production alterations.

Methods: SCAs (n=75) and HNAs (n=1726) diagnosed at our institution from 1990-2011 were retrospectively reviewed. RT-PCR was used to compare expression of ACTH-producing factors.

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Written by NEUROSURGERY® Editorial Office

April 8, 2013 at 8:00 AM

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