NEUROSURGERY Report

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Posts Tagged ‘Recurrence

Free Article: Greater Extent of Resection Improves Ganglioglioma Recurrence-Free Survival in Children

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Background: Gangliogliomas are rare, low-grade, glial-neural tumors that are most often found in children. They can recur with varying frequency; yet few data are available that adequately predict such events.

Objective: To review our institution’s large series of gangliogliomas in children and identify clinical features that predict recurrence-free survival.

Methods: Clinical records were retrospectively reviewed from 1990 to 2011. Fifty-three children were identified, and pertinent clinical features were analyzed against survival data to categorize lesions at high risk of recurrence.

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Written by NEUROSURGERY® Editorial Office

July 1, 2014 at 8:00 AM

Ahead of Print: Resection Improves Pediatric Ganglioglioma Outcome

Background: Gangliogliomas are rare, low-grade, glial-neural tumors most often found in children. They can recur with varying frequency; yet, little data are available that adequately predict such events.

Objective: To review our institution’s large series of gangliogliomas in children and identify clinical features that predict recurrence-free survival.

Methods: Clinical records were retrospectively reviewed from 1990 through 2011. Fifty-three children were identified, and pertinent clinical features were analyzed against survival data to categorize lesions at high risk for recurrence.

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Written by NEUROSURGERY® Editorial Office

May 21, 2014 at 8:00 AM

Ahead of Print: Laser Ablation for Recurrent Metastasis

Screen Shot 2014-04-08 at 1.52.58 PMBackground: Enhancing lesions that progress after stereotactic radiosurgery (SRS) are often tumor recurrence or radiation necrosis. Magnetic resonance-guided laser induced thermal therapy (LITT) is currently being explored for minimally invasive treatment of intracranial neoplasms.

Objective: To report the largest series to date of local control with LITT for the treatment of recurrent enhancing lesions after SRS for brain metastases.

Methods: Patients with recurrent metastatic intracranial tumors or radiation necrosis who had previously undergone radiosurgery and KPS>70 were eligible for LITT. Sixteen patients underwent a total of 17 procedures. The primary endpoint was local control using MRI scans at intervals of >4 weeks. Radiographic outcomes were followed prospectively until death or local recurrence (defined as >25% increase in volume when compared with the 24-hour post-procedure scan).

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Written by NEUROSURGERY® Editorial Office

May 8, 2014 at 8:00 AM

Ahead of Print: Colloid Cyst Remnants

The_Significance_of_Cyst_Remnants_FollowingBackground: Controversy surrounds the fate of cyst remnants following endoscopic colloid cyst resection.

Objective: Our study evaluated recurrence rates in patients with total endoscopic resection of colloid cysts versus those with coagulated cyst remnants.

Methods: Sixty-five consecutive patients and 67 procedures for endoscopic resection of colloid cysts from 1995 to 2011 were reviewed. Degree of resection was based upon intra-operative assessment and post-operative MRI. Recurrence rates were compared between patients with complete resection versus coagulated cyst remnants.

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Written by NEUROSURGERY® Editorial Office

May 17, 2013 at 8:00 AM

Ahead of Print: Comparison of Silent Corticotrophic Adenomas to Hormone-Negative Adenomas

Screen Shot 2013-04-08 at 7.26.21 AMBackground: Silent corticotrophic adenomas (SCAs) stain adrenocorticotropic hormone (ACTH)+ without causing Cushing’s disease. SCAs are reportedly more aggressive, but information comes from small series.

Objective: To determine whether SCAs behave more aggressively than Hormone-Negative Adenomas (HNAs), and characterize SCA ACTH production alterations.

Methods: SCAs (n=75) and HNAs (n=1726) diagnosed at our institution from 1990-2011 were retrospectively reviewed. RT-PCR was used to compare expression of ACTH-producing factors.

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Written by NEUROSURGERY® Editorial Office

April 8, 2013 at 8:00 AM

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