Posts Tagged ‘Systemic oxygenation’
Free Article: Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury
Oddo, Mauro MD; Nduom, Edjah MD; Frangos, Suzanne RN; MacKenzie, Larami MD; Chen, Isaac MD; Maloney-Wilensky, Eileen MSN; Kofke, W. Andrew MD; Levine, Joshua M. MD; LeRoux, Peter D. MD
BACKGROUND: Pulmonary complications are frequently observed after severe traumatic brain injury (TBI), but little is known about the consequences of lung injury on brain tissue oxygenation and metabolism.
OBJECTIVE: We examined the association between lung function and brain tissue oxygen tension (PbtO2) in patients with severe TBI.
METHODS: We analyzed data from 78 patients with severe, nonpenetrating TBI who underwent continuous PbtO2 and intracranial pressure monitoring. Acute lung injury was defined by the presence of pulmonary infiltrates with a PaO2/FiO2 (PF) ratio less than 300 and the absence of left ventricular failure. A total of 587 simultaneous measurements of PbtO2 and PF ratio were examined using longitudinal data analysis.
Free Article: Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury
Oddo, Mauro MD; Nduom, Edjah MD; Frangos, Suzanne RN; MacKenzie, Larami MD; Chen, Isaac MD; Maloney-Wilensky, Eileen MSN; Kofke, W. Andrew MD; Levine, Joshua M. MD; LeRoux, Peter D. MD
BACKGROUND: Pulmonary complications are frequently observed after severe traumatic brain injury (TBI), but little is known about the consequences of lung injury on brain tissue oxygenation and metabolism.
OBJECTIVE: We examined the association between lung function and brain tissue oxygen tension (PbtO2) in patients with severe TBI.
METHODS: We analyzed data from 78 patients with severe, nonpenetrating TBI who underwent continuous PbtO2 and intracranial pressure monitoring. Acute lung injury was defined by the presence of pulmonary infiltrates with a PaO2/FiO2 (PF) ratio less than 300 and the absence of left ventricular failure. A total of 587 simultaneous measurements of PbtO2 and PF ratio were examined using longitudinal data analysis. Read the rest of this entry »
