Ahead of Print: Progressive Deconstruction with Flow Diverter

Progressive_Deconstruction___A_Novel_AneurysmBackground and Importance: A variety of deconstructive and reconstructive therapies have been used to treat intracranial aneurysms. The Pipeline Embolization Device (PED) has become a quite successful option to treat aneurysms, while reconstructing and remodeling the parent vessel. We report a case of off-label PED use, where a flow diverter was placed across the parent vessel of a giant intracranial aneurysm in a novel deconstructive strategy.

Clinical Presentation: A 40 year old with a giant, slow-flow aneurym of the distal middle cerebral artery (MCA) was treated with placement of a PED across the vessel containing the aneurysm after failing superselective test balloon occlusion of that vessel. PED was successfully deployed in a competing MCA branch across the origin of the MCA branch supplying the giant aneurysm. The patient continued dual antiplatelet therapy for five months and aspirin monotherapy thereafter. Follow up angiography, performed six months after treatment, demonstrated complete and asymptomatic thrombosis of the aneurysm and its parent MCA branch. A collateral pial and leptomeningeal network developed, reconstructing the distal branches of the occluded MCA branch. After 18 months, he remains neurologically intact.

Conclusion: This appears to be the first description of progressive deconstruction for aneurysm treatment using PED. Despite not tolerating acute vessel occlusion with superselective test balloon occlusion, the patient was asymptomatic following long-term occlusion with PED secondary to growth of pial and leptomeningeal collateral networks.

From: Progressive Deconstruction: A Novel Aneurysm Treatment Using the Pipeline Embolization Device for Competitive Flow Diversion by Wajnberg et al.

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