Ahead of Print: GBM Patients’ Readmission and Survival

Background: Research on readmissions has mainly focused on the economic and resource burden it places upon hospitals.

Objective: To evaluate the effect of 30-day readmission on overall survival (OS) among newly diagnosed glioblastoma multiforme (GBM) patients.

Methods: A nationwide cohort of GBM patients diagnosed between 1991 and 2007 was studied using the Surveillance, Epidemiology and End Results (SEER) Medicare database. Multivariate models were used to determine factors associated with readmission and OS. Odds ratio (OR), hazard ratio (HR), 95% confidence interval (CI), and p-values were reported. Complete case and multiple imputation analyses were performed.

Results: Among the 2,774 newly diagnosed GBM patients undergoing surgery at 442 hospitals nationwide, 437(15.8%) were readmitted within 30 days of the index hospitalization. While 63% of readmitted patients returned to the index hospital where surgery was performed, a significant portion (37%) was readmitted to non-index hospitals. The median OS for readmitted patients (6.0 months) was significantly shorter than for non-readmitted (7.6 months, p<.0001). In a confounder adjusted imputed model, 30-day readmission increased the hazard of mortality by 30% (HR 1.3, p<.0001). Neurological symptoms (30.2%), thromboembolic complications (19.7%), and infections (17.6%) were the leading reasons for readmission.

Conclusion: Prior studies that have reported only the readmissions back to index hospitals are likely underestimating the true 30-day readmission rate. GBM patients who were readmitted within 30-days had significantly shorter survival than non-readmitted patients. Future studies that attempt to decrease readmissions and evaluate the impact of reducing readmissions on patient outcomes are needed.

From: Does Thirty-day Readmission Affect Long-term Outcome Among Glioblastoma Patients? by Patil et al.

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