Science Times: Genomic Characterization of Isocitrate Dehydrogenase-1–Mutant Glioma Malignant Progression

Over time, low-grade gliomas generally progress to become high-grade gliomas. We have learned a great deal about the development and characterization of low-grade gliomas, but we do not yet fully understand the mechanisms driving the malignant progression of these tumors. Bai et al1 systematically compared low-grade gliomas with their subsequent high-grade successors to begin answering this fundamental question. . .


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