UT Southwestern Medical Center researchers have developed an MRI-based method that can track the state and progression of a common type of genetically mutated brain cancer.
This study showed that The study showed that 2HG is an excellent biomarker for tracking certain gliomas with IDH mutations and also can provide a diagnosis when neurological risk from surgery is too high, researchers said. Researchers used MR spectroscopy, to distinguish the chemical makeup of normal vs. mutated brain tissue, to track 2HG concentrations.
The senior author of this study, Dr. Elizabeth A. Maher, explains that they can measure 2HG concentration and follow it along the disease course – noting that it is stable over long periods of time when the tumor is stable, increases when the disease progresses, and is an excellent indicator of tumor response because it falls in response to treatment that is effectively working.
Read more about this study here.