Free Article: Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature


Soft tissue sarcomas are rare tumors, representing 0.7% of all adult malignancies.1 Liposarcoma is the second most common soft tissue sarcoma after malignant fibrous histiocytoma.2 Its incidence is 15% of all soft tissue sarcomas, but less than 1% of all malignancies.3,4 Approximately one-third of liposarcomas are of the myxoid (formerly ‘round cell’) subtype, with a propensity to occur in the lower extremities. They tend to recur locally after complete excision and the metastatic rate is approximately 30%.57 The most commonly observed lower extremity liposarcoma, regardless of the tumor subtype, is in the thigh; the second most common site is the retroperitoneum.8,9 We present a case of liposarcoma of the skull base originating in the scapular region and metastasizing to the sellar and parasellar regions and provide a review of the pertinent literature.


Patient’s informed consent was obtained for the clinical presentation of this case report. The patient is a 43-year-old right-handed female smoker diagnosed in late 2004 with a 6 × 7 cm myxoid liposarcoma of the left scapular region. She had clear resection margins and was treated pre- and postoperatively with radiotherapy to the left scapular region. The patient presented in September 2006 with sudden horizontal diplopia with right lateral gaze. She did not complain of headaches, and did not present with endocrinological manifestations. Neurological examination was normal apart from right sixth cranial nerve palsy. Her laboratory investigations including hepatic and renal function tests and a detailed hormonal profile were normal.

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